Quantcast
Channel: Target validation : nature.com subject feeds
Browsing all 56 articles
Browse latest View live

Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for...

View Article



Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic...

View Article

Lateral membrane organization as target of an antimicrobial peptidomimetic...

View Article

Restoring expression of Stathmin-2: a novel strategy to treat TDP-43...

View Article

RAGE inhibitor TTP488 (Azeliragon) suppresses metastasis in triple-negative...

View Article


Targeting an allosteric site in dynamin-related protein 1 to inhibit...

View Article

Nicardipine is a putative EED inhibitor and has high selectivity and potency...

View Article

Exploring ND-011992, a quinazoline-type inhibitor targeting quinone...

View Article


Structural insights into selective small molecule activation of PKG1α

View Article


Molecular docking as a tool for the discovery of molecular targets of...

View Article

Lenalidomide derivatives and proteolysis-targeting chimeras for controlling...

View Article

Challenges in developing Geroscience trials

View Article

Anti-angiogenic therapy using the multi-tyrosine kinase inhibitor Regorafenib...

View Article


A single inhibitor for all KRAS mutations

View Article

Tamoxifen associated to the conservative CKD treatment promoted additional...

View Article


Recent advances in targeting the “undruggable” proteins: from drug discovery...

View Article

Activation of the integrated stress response by inhibitors of its kinases

View Article


Anti-methicillin-resistant Staphylococcus aureus activity and safety...

View Article

Orthosteric ligand selectivity and allosteric probe dependence at...

View Article

D-mannose induces TFE3-dependent lysosomal degradation of EGFR and inhibits...

View Article
Browsing all 56 articles
Browse latest View live




Latest Images